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1. p53 Mutants: The goal is to model mutant p53 transcriptional activity (active vs inactive) based on data extracted from biophysical simulations.

2. Arcene: ARCENE's task is to distinguish cancer versus normal patterns from mass-spectrometric data. This is a two-class classification problem with continuous input variables. This dataset is one of 5 datasets of the NIPS 2003 feature selection challenge.

3. Dorothea: DOROTHEA is a drug discovery dataset. Chemical compounds represented by structural molecular features must be classified as active (binding to thrombin) or inactive. This is one of 5 datasets of the NIPS 2003 feature selection challenge.