The clinical dataset was collected from the Internal Medicine Outpatient Clinic of Ankara VM Medical Park Hospital and includes data from 319 individuals (June 2022–June 2023), 161 of whom were diagnosed with gallstone disease. It contains 38 features, including demographic, bioimpedance, and laboratory data, and was ethically approved by the Ankara City Hospital Ethics Committee (E2-23-4632). Demographic variables are age, sex, height, weight, and BMI. Bioimpedance data includes total, extracellular, and intracellular water, muscle and fat mass, protein, visceral fat area, and hepatic fat. Laboratory features are glucose, total cholesterol, HDL, LDL, triglycerides, AST, ALT, ALP, creatinine, GFR, CRP, hemoglobin, and vitamin D. The dataset is complete, with no missing values, and balanced in terms of disease status, eliminating the need for additional preprocessing. It provides a strong foundation for machine learning-based gallstone prediction using non-imaging features.